Immune responses of mice to iodoacetate-treated Ehrlich ascites tumour cells.

Citotoxicity and Immune Response induced by Organopalladium(II) Compounds in Mice bearing Ehrlich Ascites Tumour

Os ciclometalados de paládio(II) são compostos inorgânicos reativos empregados em vários estudos biológicos devido a seu potencial antitumoral e interação com o sistema imune. Neste estudo, a resposta imune e citotóxica induzida por dois complexos organopaladados: [{Pd(N,C-dmba)}2(μ-NCS)2] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N’–dimetilbenzilamina, dppp = 1,3-bis(difenilfosfino)propano] e...

Effect of streptococcal haemolysins on Ehrlich ascites tumour cells.

Transport of calcium ions by Ehrlich ascites-tumour cells.

Ehrlich ascites-tumour cells accumulate Ca2+ when incubated aerobically with succinate, phosphate and rotenone, as revealed by isotopic and atomic-absorption measurements. Ca2+ does not stimulate oxygen consumption by carefully prepared Ehrlich cells, but des so when the cells are placed in a hypo-osmotic medium. Neither glutamate nor malate support Ca2+ uptake in 'intact' Ehrlich cells, nor do...

Modification of the Immune Response of Mice to Skin Homografts and Heterografts by Ehrlich Ascites Carcinoma.

The immunological response of mice given implants of Ehrlich ascites carcinoma was modified as evidenced by the failure of ascitic mice to reject primary or secondary skin homografts or rat skin heterografts. The site of tumor implantation influenced its effect on the host, since subcutaneously implanted Ehrlich ascites carcinoma did not alter the immune response. The presence of the tumor in t...

Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.

Treatment of Ehrlich-ascites-carcinoma-bearing mice with methylglyoxal bis(guanylhydrazone) alone or in combination with 2-difluoromethylornithine greatly enhanced the transfer of intragastrically administered radioactive putrescine and cadaverine into the carcinoma cells. Difluoromethylornithine alone did not have any effect on the accumulation of intestine-derived diamines in the tumour cells...